463356-00-5
Chemical Structure
Sordarin sodium
- CAS No.: 463356-00-5
- Formula:C27H39NaO8
- Molecular Weight:514.58
IUPAC Name: sodium (1R,3aR,4S,4aR,7R,7aR,8aS)-8a-((((2R,3S,4S,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-4-formyl-3-isopropyl-7-methyl-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylate
InChIKey: ILUKWKGTAAZHDW-IGICPMPSSA-M
SMILES: O=C(O[Na])[C@](C(C(C)C)=C[C@H]1C2)([C@]1(CO[C@@H]([C@@H](O)[C@H](O)[C@@H]3OC)O[C@@H]3C)C[C@]4([C@]5(CC[C@H]4C)[H])[H])[C@]25C=O
Biological Activity: Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sordarin sodium | 99.0% | Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity. | ||||||||||||||||||||
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- [1]. Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel). 2013 May 3;5(5):958-68. [Content Brief]
- [2]. Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42. [Content Brief]
Keywords
