1. Anti-infection
  2. Fungal
    Antibiotic
  3. Naftifine hydrochloride

Naftifine hydrochloride 

Cat. No.: HY-B0518A Purity: 99.38%
Handling Instructions

Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.

For research use only. We do not sell to patients.

Naftifine hydrochloride Chemical Structure

Naftifine hydrochloride Chemical Structure

CAS No. : 65473-14-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 157 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 157 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 143 In-stock
Estimated Time of Arrival: December 31
1 g USD 238 In-stock
Estimated Time of Arrival: December 31
5 g USD 726 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Other Forms of Naftifine hydrochloride:

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Description

Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].

In Vitro

Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration (MIC) range 0.1 to 0.2 mg/mL), aspergilli (6 strains; MIC range, 0.8 to 12.5 mg/mL), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 mg/mL), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 mg/mL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

323.86

Formula

C21H22ClN

CAS No.
SMILES

CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C23.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (308.78 mM; Need ultrasonic)

Ethanol : 25 mg/mL (77.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0878 mL 15.4388 mL 30.8775 mL
5 mM 0.6176 mL 3.0878 mL 6.1755 mL
10 mM 0.3088 mL 1.5439 mL 3.0878 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.72 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Naftifine hydrochloride
Cat. No.:
HY-B0518A
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