Nonoxynol-9 

Nonoxynol-9 is a nonionic detergent. Nonoxynol-9 inhibits SOD activity. Nonoxynol-9 exhibits activity against diverse microbes and pathogens. Nonoxynol-9 can be used for the research of HIV infection^[1][2][3].

Nonoxynol-9 (0.0625-0.5 mg/mL) potently reduces viability of human sperm in a concentration-dependent manner^[1].
Nonoxynol-9 disrupts membrane integrity, damages organelles (including mitochondria and nuclei), induces intracellular acidification, alters redox balance, inhibits capacitation-related signaling, and reduces zona pellucida binding of human sperm^[1].
Nonoxynol-9 (1-100 μg/mL; 1 min) induces a dose-dependent reduction in washed boar sperm motility^[2].
Nonoxynol-9 (0.05%; 30 s) directly inactivates HIV virions, and blocks infection of HIV-pulsed cells^[3].
Nonoxynol-9 exhibits in vitro activity against a range of sexually transmitted infection pathogens including HSV, cytomegalovirus, and multiple bacterial and protozoal species^[3].
Nonoxynol-9 (0.00025%; 24-48 h; or 2 h daily for 3 days) causes cumulative cytotoxicity in primary vaginal epithelial cells, and repeat 2-hour daily exposures over 3 days increasing cytotoxicity^[3].
Nonoxynol-9 (6-24 h) induces proinflammatory cytokine release (IL-1a, IL-1b, IL-8) in primary vaginal epithelial cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nonoxynol-9 (2%; topical vaginal; single 20 μL dose) causes extensive epithelial cell death in Progesterone (HY-N0437)-treated mice with columnar cervicovaginal epithelium^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

616.83

C₃₃H₆₀O₁₀

14409-72-4

Liquid

OCCOCCOCCOCCOCCOCCOCCOCCOCCOC1=CC=C(C=C1)CCCCCCCCC

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Xu M, et al. Effects of nonoxynol-9 (N-9) on sperm functions: systematic review and meta-analysis. Reprod Fertil. 2022;3(1):R19-R33. Published 2022 Feb 21.

  [2]. Ingram MJ, et al. Synthesis and spermicidal activity of a putative nitric oxide-releasing derivative of nonoxynol-9. Contraception. 2004;70(1):73-76.

  [3]. Hillier SL, et al. In vitro and in vivo: the story of nonoxynol 9. J Acquir Immune Defic Syndr. 2005 May 1;39(1):1-8.  [Content Brief]