Leucinostatin A
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies.
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- CAS No.: 76600-38-9
- 화학식: C62H111N11O13
- 분자량:1218.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- 순도&문서
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Biological Activity
제품 설명
Chemical Information
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CAS No. 76600-38-9
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분자량 1218.61
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화학식 C62H111N11O13
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SMILES
[P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}]
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Synonyms
Antibiotic P168
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Sequence Shortening
P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}
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Structure Classification
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Initial Source
Paecilomyces lilacinus
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132. [Content Brief]
[2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72. [Content Brief]
[3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leucinostatin A Related Classifications
HY-P2450 Related Classifications
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