2. Metabolic Enzyme/Protease Anti-infection
  3. Cytochrome P450 Fungal
  4. Tebuconazole-d9

Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.

For research use only. We do not sell to patients.

Tebuconazole-d<sub>9</sub> Chemical Structure

Tebuconazole-d9 Chemical Structure

CAS No. : 1246818-83-6

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Other Forms of Tebuconazole-d9:

Tebuconazole-d9 Related Antibodies

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View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tebuconazole-d9 Related Antibodies

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 20,40,80 μM
Incubation Time: 1–12 hours
Result: Increased the nuclear translocation of peroxisome proliferator-activated receptors and the expression of cluster of differentiation 36, fatty acid transport protein (FATP) 2, FATP5, and carnitine palmitoyltransferase 1.

Apoptosis Analysis[3]

Cell Line: Bovine mammary gland epithelial cells (MAC-T cells)
Concentration: 100,150,200,250,500,750 μM
Incubation Time: 24 hours
Result: Decreased cells viability and proliferation and activates apoptotic cell death via the upregulation of pro-apoptotic proteins, such as cleaved caspases 3 and 8 and BAX.
Induced loss of mitochondrial membrane potential in MAC-T cells.
Induced mitochondria-mediated apoptotic MAC-T cell death by activating ER stress.
Induced endoplasmic reticulum (ER) stress via the upregulation of Bip/GRP78; PDI; ATF4; CHOP; and ERO1-Lα.
Molecular Weight

316.87

Formula

C16H13D9ClN3O
CAS No.
SMILES

OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(CCC1=CC=C(Cl)C=C1)CN2C=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tebuconazole-d9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tebuconazole-d91246818-83-6Cytochrome P450FungalCYPsInhibitorinhibitorinhibit

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