2. Anti-infection
  3. Fungal
  4. Ac-CoA-IN-1

Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections.

For research use only. We do not sell to patients.

Ac-CoA-IN-1

Ac-CoA-IN-1 Chemical Structure

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Ac-CoA-IN-1 Related Antibodies

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Description

Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections[1].

In Vitro

Ac-CoA-IN-1 (50 μM; 13.6-83.7 mM IC50 range) inhibits purified Candida albicans ACS2 with an IC50 of 13.6 mM and shows minimal activity against purified Cryptococcus neoformans ACS1, with an IC50 of 83.7 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-CoA-IN-1 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax AUC0-last MRT Bioavailability
Rat[1] 100 mg/kg p.o. 20.0 ng/mL 0.61 h 15.4 ng·h/mL 1.27 h 12.1 %
Molecular Weight

359.36

Formula

C11H17N7O5S
SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CNS(NC)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ac-CoA-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-CoA-IN-1Fungalfungal infectionsCryptococcus neoformansTHR 441propyl AMP binding siteCandida albicans acetyl-CoA synthetase 2TRP 334TYR 438Candida albicansASP 527Cryptococcus neoformans acetyl-CoA synthetase 1Inhibitorinhibitorinhibit

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