Ac-CoA-IN-1
Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections.
For research use only. We do not sell to patients.
- Formula: C11H17N7O5S
- Molecular Weight:359.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ac-CoA-IN-1 (50 μM; 13.6-83.7 mM IC50 range) inhibits purified Candida albicans ACS2 with an IC50 of 13.6 mM and shows minimal activity against purified Cryptococcus neoformans ACS1, with an IC50 of 83.7 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | AUC0-last | MRT | Bioavailability |
|---|---|---|---|---|---|---|---|
| Rat[1] | 100 mg/kg | p.o. | 20.0 ng/mL | 0.61 h | 15.4 ng·h/mL | 1.27 h | 12.1 % |
Chemical Information
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Molecular Weight 359.36
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Formula C11H17N7O5S
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SMILES
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CNS(NC)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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