1. Anti-infection
  2. Fungal
  3. VT-1598

VT-1598 

Cat. No.: HY-123777
Handling Instructions

VT-1598 is an orally active, novel and selective fungal CYP51 inhibitor. VT-1598 shows anti-fungal activity against Candida auris.

For research use only. We do not sell to patients.

VT-1598 Chemical Structure

VT-1598 Chemical Structure

CAS No. : 2089320-99-8

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Description

VT-1598 is an orally active, novel and selective fungal CYP51 inhibitor. VT-1598 shows anti-fungal activity against Candida auris[1][2].

In Vitro

VT-1598 (0.015-8 μg/mL; 24 h) demonstrates in vitro activity against C. auris[1].
VT-1598 (0.03125-0.125 μg/mL; 24 h) shows highly effects in inhibiting the in vitro growth of clinical Candida isolates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 100 C. auris isolates
Concentration: 0.015-8 μg/mL
Incubation Time: 24 hours
Result: Showed MICs ranging from 0.03 to 8 μg/ mL against all isolates, with MIC50 and MIC90 values of 0.25 and 1 μg/mL, respectively.

Cell Viability Assay[2]

Cell Line: 28 Candida isolates obtained from mucosal sites of APECED patients
Concentration: 0.03125-0.125 μg/mL
Incubation Time: 24 hours
Result: Demonstrated potent in vitro activity against all 28 isolates (MIC range=0.03125-0.125 mg/L), with the MIC50 and MIC90 values of 0.0625 and 0.125 mg/L, respectively.
In Vivo

VT-1598 (oral gavage; 5, 15, and 50 mg/kg; once daily; 7 d) treatment shows a significant and dose-dependent survival advantage, and dose-dependent reductions in fungal burden[1].
VT-1598 (oral gavage; 3.2, 8, and 20 mg/kg; once daily; 4 d) is present to a great extent in the plasma and tongue after oral administration in Act1-deficient mice infected with C. albicans[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice model of invasive candidiasis[1]
Dosage: 5, 15, and 50 mg/kg
Administration: Oral gavage; 5, 15, and 50 mg/kg; once daily; 7 days
Result: Observed median survival in the VT-1598 15 mg/kg and 50 mg/kg groups (15 days and >21 days, respectively) longer than the control group.
Observed kidney fungal burden in mice treated with 15 mg/kg and 50 mg/kg doses (mean log10 CFU/g, 5.40 and 3.67, respectively) lower than the vehicle control group.
Showed mean trough concentrations 1.55 μg/mL after 7 days of therapy in the 5 mg/kg group, 6.78 μg/mL in the 15 mg/kg group, and 14.2 μg/mL in the 50 mg/kg group.
Animal Model: Act1-deficient mice infected with C. albicans[2]
Dosage: 3.2, 8, and 20 mg/kg
Administration: Oral gavage; 3.2, 8, and 20 mg/kg; once daily; 4 days
Result: Resulted in high concentrations in the plasma and tongues of Candida-infected mice.
Molecular Weight

584.52

Formula

C31H20F4N6O2

CAS No.
SMILES

N#CC1=CC=C(COC2=CC=C(C#CC3=CC=C(C(F)(F)[[email protected]@](O)(C4=CC=C(F)C=C4F)CN5N=NN=C5)N=C3)C=C2)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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