Tylophorinicine
Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine.
For research use only. We do not sell to patients.
- CAS No.: 87302-57-6
- Formula: C24H27NO5
- Molecular Weight:409.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>300 nM
Compound: DCB-3501
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Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay
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[PMID: 17531481] |
| HepG2 | IC50 |
315 nM
Compound: DCB-3501
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Inhibition of NF-kappaB-mediated gene transcription in HepG2 cells by luciferase reporter gene assay
Inhibition of NF-kappaB-mediated gene transcription in HepG2 cells by luciferase reporter gene assay
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[PMID: 17531481] |
| RAW264.7 | IC50 |
1057 nM
Compound: 5, DCB-3501
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Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
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[PMID: 25221661] |
| RAW264.7 | IC50 |
350 nM
Compound: 5, DCB-3501
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
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[PMID: 25221661] |
| Splenocyte | IC50 |
1292 nM
Compound: 5, DCB-3501
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Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
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[PMID: 25221661] |
| Splenocyte | IC50 |
370 nM
Compound: 5, DCB-3501
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Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
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[PMID: 25221661] |
Chemical Information
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CAS No. 87302-57-6
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Molecular Weight 409.47
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Formula C24H27NO5
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SMILES
O[C@@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mostafa EM, et al., In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica. Plants (Basel). 2022 May 12;11(10):1295. [Content Brief]
[3]. Dhiman M, et al., Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine. Nat Prod Commun. 2012 Sep;7(9):1171-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tylophorinicine Related Classifications
HY-124900 Related Classifications
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