87302-57-6
Chemical Structure
Tylophorinicine
- CAS No.: 87302-57-6
- Formula:C24H27NO5
- Molecular Weight:409.47
IUPAC Name: (13aS,14R)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinolin-14-ol
InChIKey: JWHWLMNMGLICQZ-UUOWRZLLSA-N
SMILES: O[C@@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5
Biological Activity: Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine[1][2][3].
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Tylophorinicine | Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine. | |||||||||||||||||||||
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- [1]. Mostafa EM, et al., In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica. Plants (Basel). 2022 May 12;11(10):1295. [Content Brief]
- [2]. N.B. Mulchandani and S.R. Venkatachalam. Tylophorinicine, a phenanthroindolizidine alkaloid from tylophora asthmatica and pergularia pallida. (1984) 23(5) 1206.
- [3]. Dhiman M, et al., Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine. Nat Prod Commun. 2012 Sep;7(9):1171-2. [Content Brief]
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