Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine

  • Nat Prod Commun. 2012 Sep;7(9):1171-2.
Mini Dhiman  1 ,  Rajashri R Parab ,  Sreedharannair L Manju ,  Dattatraya C Desai ,  Girish B Mahajan
Affiliations
  • 1. Special Projects Analytical Chemistry, Piramal Healthcare Limited, Mumbai-400063, India.
PMID: 23074899
Abstract

The antimicrobial efficacy of two phenanthroindolizidine Alkaloids, tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), isolated from the plant Tylophora indica (local name, Antamul) was evaluated. These were screened for in vitro Antifungal and Antibacterial activities. Both compounds exhibited potent Antifungal activity displaying minimum inhibitory concentrations (MIC) in the range of 2-4 microg/mL for TdnH and 0.6-2.5 microg/mL for TnnH against Candida species.

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