P-gp-IN-34 

P-gp-IN-34 (compound 4a) is an Mdr1p (Mdr1 pump) inhibitor. P-gp-IN-34 inhibits yeast to hyphal shift in Candida albicans. P-gp-IN-34 can be used for the research of candidiasis^[1].

P-gp-IN-34 (compound 4a) combined with fluconazole reduces Candida albicans cell counts by ~6 log fold in Mdr1-expressing strains by 48 h, with no effect in Mdr1 knockout strains^[1].
P-gp-IN-34 (compound 4a) (64-128 μg/mL; 24 h) inhibits Candida albicans biofilm formation by 70–80%^[1].
P-gp-IN-34 (compound 4a) combined with fluconazole (16 h) reduces intracellular Candida albicans counts by 2 log fold in RAW macrophages^[1].
P-gp-IN-34 (compound 4a) stabilizes the Mdr1 pump of Candida albicans and forms stable interactions with key residues TRP248 and ARG503^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

315.82

C₁₆H₁₄ClN₃S

2743456-25-7

CC1=NN(C(N)=C1SC2=CC=C(Cl)C=C2)C3=CC=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Unnikrishnan VK, et al. Evaluation of the efflux inhibitory potential of aminopyrazole derivative to restore azole sensitivity in Candida albicans. Bioorg Med Chem Lett. 2026;133:130529.  [Content Brief]