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  4. Pyrithioxin

Pyrithioxin  (Synonyms: Pyritinol; Pyridoxine disulfide; Vitamin B6 disulfide)

Cat. No.: HY-B0910
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Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis.

For research use only. We do not sell to patients.

Pyrithioxin

Pyrithioxin Chemical Structure

CAS No. : 1098-97-1

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Based on 2 publication(s) in Google Scholar

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Pyrithioxin Related Antibodies

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Description

Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis[1][2][3][4][5][6][7].

In Vitro

Pyrithioxin (dihydrochloride) (0.5-3 μg/mL) increases D-arabitol production from Candida parapsilosis by regulating glucose-6-phosphate dehydrogenase[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrithioxin Related Antibodies
In Vivo

Pyrithioxin (20 mg/kg, i.g., five times a week) prolongs survival time and induces tumor remission in WISTAR rats with 3-MC-induced subcutaneous fibrosarcomas[2].
Pyrithioxin (200 and 600 mg/kg diet, added to the feed for free consumption, 6 weeks) elevates acetylcholine levels and enhances memory behavior in rats[4].
Pyrithioxin (50-200 mg/kg, p.o.) reduces flinching behavior in Streptozocin (HY-13753)-induced diabetic rats[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WISTAR rats with 3-MC-induced subcutaneous fibrosarcomas[2]
Dosage: 20 mg/kg
Administration: Orally gavage, five times a week after tumor appearance or after tumor resection
Result: Showed remission rate 11%-12%.
Partial recurrence control was achieved in remitted rats with small tumors (0.7-1 cm in diameter) under continuous administration.
Clinical Trial
Molecular Weight

368.47

Formula

C16H20N2O4S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Pyrithioxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrithioxin1098-97-1Pyritinol Pyridoxine disulfide Vitamin B6 disulfideDrug DerivativeDrug derivativeGlucoseAmino acidsCerebral infarctEpilepsyFibrosarcomasRheumatoid polyarthritisD-arabitolCandida parapsilosis3-MCAcetylcholineInhibitorinhibitorinhibit

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