1. Cell Cycle/DNA Damage
    Apoptosis
  2. Polo-like Kinase (PLK)
    CDK
    DAPK
  3. 3MB-PP1

3MB-PP1 

Cat. No.: HY-102069
Handling Instructions

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division.

For research use only. We do not sell to patients.

3MB-PP1 Chemical Structure

3MB-PP1 Chemical Structure

CAS No. : 956025-83-5

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Description

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].

IC50 & Target[3]

Leu93-ZIPK

2 μM (IC50)

In Vitro

3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

295.38

Formula

C17H21N5

CAS No.
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Storage

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3MB-PP1
Cat. No.:
HY-102069
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