1. Anti-infection
  2. Fungal
  3. Ibrexafungerp citrate

Ibrexafungerp citrate (Synonyms: MK 3118 citrate; SCY-078 citrate)

Cat. No.: HY-107126A
Handling Instructions

Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections.

For research use only. We do not sell to patients.

Ibrexafungerp citrate Chemical Structure

Ibrexafungerp citrate Chemical Structure

CAS No. : 1965291-08-0

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Description

Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections[1].

In Vitro

Ibrexafungerp citrate (MK 3118 citrate) leads to fungicidal activity against various Candida spp., with a minimum inhibitory concentration (MIC50) of 0.5 µg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic Analysis
Ibrexafungerp citrate (MK 3118 citrate) exhibits oral bioavailability (mouse 51%, rat 45%, dog 35%) following oral administration (mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg)[3].
Ibrexafungerp citrate (MK 3118 citrate) exhibits moderate half-lives (mouse 5.5, rat 8.7 and, dog 9.3 h) due to high plasma clearance (0.68, 0.44, and 0.45 L/h/kg respectively) combined with large volumes of distribution (5.3, 4.7, and 4.1 L/kg respectively) following intravenous administration (mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD1 mice, Male and female Han Wister rats, Male and female beagle dogs[3]
Dosage: Mice (1 mg/kg), rats (5 mg/kg) and dogs (5 mg/kg)
Administration: Intravenous (i.v.) or oral gavage
Result: T1/2s of 5.5, 8.7, and 9.3 h for mice, rats, and dogs, respectively.
Molecular Weight

922.16

Formula

C₅₀H₇₅N₅O₁₁

CAS No.

1965291-08-0

SMILES

C[[email protected]@]12[[email protected]@](CC3)([H])[[email protected]@](C[[email protected]](N4C(C5=CC=NC=C5)=NC=N4)([H])[[email protected]@H]1OC[[email protected]](C)(N)C(C)(C)C)(COC2)C([[email protected]@]3([H])[[email protected]]6(CC[[email protected]]7(C)[[email protected]](C)C(C)C)C)=CC[[email protected]]6([[email protected]@H]7C(O)=O)C.OC(CC(C(O)=O)(O)CC(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IbrexafungerpMK 3118SCY-078MK3118MK-3118SCY078SCY 078Fungalβ-1,3-glucanantifungalcandidaInhibitorinhibitorinhibit

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