Aspergillusidone F
Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 1558007-47-8
- Formula: C19H16Br2O5
- Molecular Weight:484.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
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Aromatase 0.5 μM (IC50) |
Fungal Metabolite |
In Vitro
Aspergillusidone F potently inhibits aromatase with an IC50 of 0.5 μM[1].
Aspergillusidone F exhibits weak cytotoxic activity against HuCCA-1, HepG2, A549 and MOLT-3 cell lines, with IC50 values of 45.0, 35.3, 48.0 and 14.4 μg mL−1[1], respectively.
Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus[2].
Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM[2].
Aspergillusidone F shows no significant acetylcholinesterase (AChE) inhibitory activity[2].
Aspergillusidone F exhibits no significant DPPH free radical scavenging activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1558007-47-8
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Molecular Weight 484.14
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Formula C19H16Br2O5
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SMILES
C/C=C(C1=C2C(OC(C3=C(C)C=C(O)C(Br)=C3O2)=O)=C(C(O)=C1Br)C)\C
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Structure Classification
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Initial Source
Aspergillus unguis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aspergillusidone F Related Classifications
HY-N16403 Related Classifications
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