2. Metabolic Enzyme/Protease Anti-infection Others
  3. Cytochrome P450 Endogenous Metabolite Bacterial Insecticide Fungal
  4. Aspergillusidone F

Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia.

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Aspergillusidone F

Aspergillusidone F Chemical Structure

CAS No. : 1558007-47-8

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Aspergillusidone F Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Human Endogenous Metabolite Microbial Metabolite

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Description

Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia[1][2].

IC50 & Target[1][2]

Aromatase

0.5 μM (IC50)

Fungal Metabolite

 

In Vitro

Aspergillusidone F potently inhibits aromatase with an IC50 of 0.5 μM[1].
Aspergillusidone F exhibits weak cytotoxic activity against HuCCA-1, HepG2, A549 and MOLT-3 cell lines, with IC50 values of 45.0, 35.3, 48.0 and 14.4 μg mL−1[1], respectively.
Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus[2].
Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM[2].
Aspergillusidone F shows no significant acetylcholinesterase (AChE) inhibitory activity[2].
Aspergillusidone F exhibits no significant DPPH free radical scavenging activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aspergillusidone F Related Antibodies
Molecular Weight

484.14

Formula

C19H16Br2O5
CAS No.
SMILES

C/C=C(C1=C2C(OC(C3=C(C)C=C(O)C(Br)=C3O2)=O)=C(C(O)=C1Br)C)\C
Structure Classification
Initial Source

Aspergillus unguis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aspergillusidone F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspergillusidone F1558007-47-8Cytochrome P450Endogenous MetaboliteBacterialInsecticideFungalCYPsA549HuCCA-1MOLT-3aromataseCandida albicansPseudomonas aeruginosamethicillin-resistant Staphylococcus aureusArtemia salinaHepG2Vibrio parahemolyticusInhibitorinhibitorinhibit

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