Aspergillusidone F
Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 1558007-47-8
- Formula: C19H16Br2O5
- Molecular Weight:484.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Aromatase 0.5 μM (IC50) |
Fungal Metabolite |
Aspergillusidone F potently inhibits aromatase with an IC50 of 0.5 μM[1].
Aspergillusidone F exhibits weak cytotoxic activity against HuCCA-1, HepG2, A549 and MOLT-3 cell lines, with IC50 values of 45.0, 35.3, 48.0 and 14.4 μg mL−1[1], respectively.
Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus[2].
Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM[2].
Aspergillusidone F shows no significant acetylcholinesterase (AChE) inhibitory activity[2].
Aspergillusidone F exhibits no significant DPPH free radical scavenging activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1558007-47-8
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Molecular Weight 484.14
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Formula C19H16Br2O5
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SMILES
C/C=C(C1=C2C(OC(C3=C(C)C=C(O)C(Br)=C3O2)=O)=C(C(O)=C1Br)C)\C
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Structure Classification
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Initial Source
Aspergillus unguis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aspergillusidone F Related Classifications
HY-N16403 Related Classifications
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