1558007-47-8
Chemical Structure
Aspergillusidone F
- CAS No.: 1558007-47-8
- Formula:C19H16Br2O5
- Molecular Weight:484.14
IUPAC Name: (E)-4,7-dibromo-6-(but-2-en-2-yl)-3,8-dihydroxy-1,9-dimethyl-11H-dibenzo[b,e][1,4]dioxepin-11-one
InChIKey: RIWKHDRNBKZCAT-FNORWQNLSA-N
SMILES: C/C=C(C1=C2C(OC(C3=C(C)C=C(O)C(Br)=C3O2)=O)=C(C(O)=C1Br)C)\C
Biological Activity: Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia[1][2].
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Aspergillusidone F | Aspergillusidone F is a Depsidone and antibacterial agent. Aspergillusidone F can be isolated from a marine fungus Aspergillus unguis. Aspergillusidone F potently inhibits Aromatase with an IC50 of 0.5 μM. Aspergillusidone F exhibits antibacterial activity against Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. Aspergillusidone F exhibits potent larvicidal activity against Artemia salina larvae, with an LC50 value of 12.8 μM. Aspergillusidone F exhibits anticancer activity against intrahepatic cholangiocarcinoma, non-small cell lung cancer, and acute lymphoblastic leukemia. | |||||||||||||||||||||
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- [1]. Sureram S, et al. Directed biosynthesis through biohalogenation of secondary metabolites of the marine-derived fungus Aspergillus unguis[J]. RSC advances, 2013, 3(6): 1781-1788.
- [2]. Yang WC, et al. Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant. Molecules. 2018 Sep 3;23(9):2245. [Content Brief]
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