1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Integrin
  5. Integrin alpha V beta 6
  6. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His)

Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His)

Cat. No.: HY-P73866
Handling Instructions

Integrin alpha V beta 6 protein, a key member of the integrin superfamily, crucially engages in cell adhesion and signaling through heterodimer formation with beta chains, including beta 1, beta 3, beta 6, and beta 8. As the Vitronectin receptor, the alpha V beta 3 heterodimer interacts with multiple extracellular matrix proteins, mediating cell adhesion and influencing cell migration. Its deficiency in mice leads to vascular morphogenesis defects in the brain and early post-natal mortality. Integrin alpha V beta 6 is widely expressed, notably in tissues like adult placenta and ovary. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His), has molecular weight of ~190.4 kDa.

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Description

Integrin alpha V beta 6 protein, a key member of the integrin superfamily, crucially engages in cell adhesion and signaling through heterodimer formation with beta chains, including beta 1, beta 3, beta 6, and beta 8. As the Vitronectin receptor, the alpha V beta 3 heterodimer interacts with multiple extracellular matrix proteins, mediating cell adhesion and influencing cell migration. Its deficiency in mice leads to vascular morphogenesis defects in the brain and early post-natal mortality. Integrin alpha V beta 6 is widely expressed, notably in tissues like adult placenta and ovary. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His), has molecular weight of ~190.4 kDa.

Background

Integrin alpha V beta 6 protein, a member of the integrin superfamily, plays a crucial role in cell adhesion and signaling by forming heterodimers with various beta chains, including beta 1, beta 3, beta 6, and beta 8. The alpha V beta 3 heterodimer functions as the Vitronectin receptor. Interacting with multiple extracellular matrix proteins, this protein mediates cell adhesion and is implicated in cell migration. In mice, the deficiency of this gene is linked to vascular morphogenesis defects in the brain and early post-natal mortality. The expression of Integrin alpha V beta 6 protein is widespread, observed in various tissues such as adult placenta and ovary.

Species

Mouse

Source

HEK293

Tag

C-His;C-Flag

Accession

NP_032428.2 (F31-V988)&NP_067334 (G22-P708)

Gene ID

16410  [NCBI]&16420

Molecular Construction
N-term
ITGAV (F31-V988)
Accession # NP_032428.2
Flag
C-term
N-term
ITGB6 (G22-P708)
Accession # NP_067334
His
C-term
Synonyms
CD51; Integrin alpha V beta 6; integrin subunit alpha V; ITGAV; MSK8; VNRA; VTNR
Molecular Weight

Approximately 190.4 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His)
Cat. No.:
HY-P73866
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