Integrin alpha 10 beta 1 Protein, Human (HEK293, His)
Integrin α-10/β-1 is a collagen-specific receptor that plays a crucial role in mediating cell interactions with the extracellular matrix. It consists of alpha-10 and beta-1 subunits, which stably associate to form a heterodimeric complex. Integrin alpha 10 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 10 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Integrin α-10/β-1 is a collagen-specific receptor that plays a crucial role in mediating cell interactions with the extracellular matrix. It consists of alpha-10 and beta-1 subunits, which stably associate to form a heterodimeric complex. Integrin alpha 10 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 10 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.
Background
Integrin alpha-10/beta-1, a cell surface receptor, plays a pivotal role as a specific receptor for collagen, mediating cellular interactions with the extracellular matrix. This integrin functions as a heterodimer, consisting of an alpha-10 subunit and a beta-1 subunit. The alpha-10 subunit forms a crucial association with the beta-1 subunit, creating a stable heterodimeric complex. Through this interaction, Integrin alpha-10/beta-1 contributes to various cellular processes by facilitating adhesion and signaling events in response to collagen, thereby influencing crucial aspects of cell behavior and tissue organization. Unraveling the nuances of Integrin alpha-10/beta-1's interactions provides insights into its significance in mediating cell-matrix interactions and its potential implications in physiological and pathological contexts.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-8*His
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Accession
O75578-1 (F23-S1122)&P05556-1 (Q21-D728)
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Gene ID8515&3688
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Synonyms
ITGA10; Integrin, Alpha 10; Integrin Subunit Alpha 10; PRO827; Integrin Alpha-10; ITGB1; Very Late Activation Protein, Beta Polypeptide; Prev. MSK12; Integrin VLA-4 Beta Subunit; Prev. FNRB; VLA-4 Subunit Beta; Prev. MDF2; Integrin Beta 1; GPIIA; Integrin
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Predicted Molecular Mass
125.6 kDa (ITGA10) & 83.2 kDa (ITGB1)
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Molecular Weight
Approximately 130-160 kDa (ITGA10) & 110-120 kDa (ITGB1), based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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