Integrin alpha 10 beta 1
Integrin alpha 10 beta 1 is the principal collagen II receptor of chondrocytes, assembled from the alpha-10 subunit encoded by ITGA10 and beta-1. Its I-domain binds triple-helical collagen II, making it essential for growth plate cartilage organization and skeletal development; mutations disrupting alpha 10 beta-1 function have been associated with osteoarthritis and with cartilage defects in animals. Expression is concentrated in cartilage, osteoblasts and intervertebral disc, with lower levels in brain and heart. Beyond matrix adhesion, the receptor influences chondrocyte differentiation and mechanotransduction. Recombinant alpha 10 protein supports studies of cartilage matrix interactions and of osteoarthritis mechanisms, an area where this integrin is comparatively specialized.
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Integrin alpha 10 beta 1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
