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XVA143 

Cat. No.: HY-139202
Handling Instructions

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo.

For research use only. We do not sell to patients.

XVA143 Chemical Structure

XVA143 Chemical Structure

CAS No. : 264275-77-6

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Description

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].

In Vitro

XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism[1]. XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: K562 cells.
Concentration: 0, 0.2, 0.5 and 1 μM.
Incubation Time:
Result: Potent against the weakest activator (2 mM Mg2+/1 mM EGTA, IC50 ~10-3 nM) and least potent against the strongest activator (1 mM Mn2+, IC50 ~10-3 nM).

Cell Viability Assay[1]

Cell Line: Wild-type murine lymphocytes[1].
Concentration: 100 μM.
Incubation Time:
Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27±5% to 41±7%).
Molecular Weight

562.36

Formula

C₂₅H₂₁Cl₂N₃O₈

CAS No.
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XVA143
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