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ITGB6 Protein, Mouse (HEK293, His)

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ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion..Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1.ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • ITGB6 Protein, Mouse (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion..Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1.ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag.

Background

The Integrin alpha-V:beta-6 protein (ITGAV:ITGB6) operates as a versatile receptor, recognizing the R-G-D sequence in its ligands such as fibronectin and cytotactin. Additionally, ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. A crucial role of ITGAV:ITGB6 is highlighted in the mediation of R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from the regulatory Latency-associated peptide (LAP), playing a key role in TGF-beta-1 activation. Structurally, ITGAV:ITGB6 forms a heterodimer, consisting of an alpha and a beta subunit. It interacts with FLNB and HAX1, underscoring its involvement in various cellular processes. Furthermore, ITGAV:ITGB6 interacts with FBN1 and TGFB1, emphasizing its integral role in cell adhesion and the activation of TGF-beta-1 signaling pathways. This diverse range of interactions establishes ITGAV:ITGB6 as a pivotal player in cellular responses and regulatory mechanisms.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-8*His
  • Accession

    Q9Z0T9 (G22-N706)

  • Gene ID
    16420  [NCBI]
  • Molecular Construction
    • N-term
    • ITGB6 (G22-N706)
      Accession # Q9Z0T9
    • 8*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    ITGB6; Integrin Beta-6; Integrin Subunit Beta 6; Integrin Beta; Integrin, Beta 6; AI1H

  • AA Sequence

    GCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIHNINEKDCPKPPN

  • Predicted Molecular Mass

    75.7 kDa

  • Molecular Weight

    Approximately 80-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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