ITGB6 Protein, Mouse (HEK293, His)

ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion..Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1.ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag.

The Integrin alpha-V:beta-6 protein (ITGAV:ITGB6) operates as a versatile receptor, recognizing the R-G-D sequence in its ligands such as fibronectin and cytotactin. Additionally, ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. A crucial role of ITGAV:ITGB6 is highlighted in the mediation of R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from the regulatory Latency-associated peptide (LAP), playing a key role in TGF-beta-1 activation. Structurally, ITGAV:ITGB6 forms a heterodimer, consisting of an alpha and a beta subunit. It interacts with FLNB and HAX1, underscoring its involvement in various cellular processes. Furthermore, ITGAV:ITGB6 interacts with FBN1 and TGFB1, emphasizing its integral role in cell adhesion and the activation of TGF-beta-1 signaling pathways. This diverse range of interactions establishes ITGAV:ITGB6 as a pivotal player in cellular responses and regulatory mechanisms.

Mouse

HEK293

C-8*His

Q9Z0T9 (G22-N706)

16420  [NCBI]

Extracellular Domain

GCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIHNINEKDCPKPPN

Approximately 80-115 kDa,based on Bis-Tris PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.