1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Integrin
  5. Integrin beta 6
  6. ITGB6 Protein, Mouse (HEK293, His)

ITGB6 Protein, Mouse (HEK293, His)

Cat. No.: HY-P700769
Handling Instructions

ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion. . Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1. ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of ITGB6 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 80-115 kDa.

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Description

ITGB6 is a multifunctional receptor that recognizes RGD sequences in ligands such as fibronectin, chemoattractants, and fibrillin-1 (FBN1) and plays a key role in mediating RGD-dependent cell adhesion. . Its key functions include the release of transforming growth factor beta-1 (TGF-beta-1) from latency-associated peptide (LAP), thereby activating TGF-beta-1. ITGB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of ITGB6 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 80-115 kDa.

Background

The Integrin alpha-V:beta-6 protein (ITGAV:ITGB6) operates as a versatile receptor, recognizing the R-G-D sequence in its ligands such as fibronectin and cytotactin. Additionally, ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. A crucial role of ITGAV:ITGB6 is highlighted in the mediation of R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from the regulatory Latency-associated peptide (LAP), playing a key role in TGF-beta-1 activation. Structurally, ITGAV:ITGB6 forms a heterodimer, consisting of an alpha and a beta subunit. It interacts with FLNB and HAX1, underscoring its involvement in various cellular processes. Furthermore, ITGAV:ITGB6 interacts with FBN1 and TGFB1, emphasizing its integral role in cell adhesion and the activation of TGF-beta-1 signaling pathways. This diverse range of interactions establishes ITGAV:ITGB6 as a pivotal player in cellular responses and regulatory mechanisms.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

Q9Z0T9 (G22-N706)

Gene ID

16420  [NCBI]

Molecular Construction
N-term
ITGB6 (G22-N706)
Accession # Q9Z0T9
His
C-term
Synonyms
Integrin beta-6; ITGB6; Integrin β-6
Molecular Weight

80-115 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ITGB6 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ITGB6 Protein, Mouse (HEK293, His)
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HY-P700769
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