Itgb6 - integrin beta 6 Gene

Also Known as 2210409C20Rik; 4831415H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16420

Summary

Enables Integrin binding activity. Involved in cell adhesion mediated by Integrin and transforming growth factor beta production. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; hard palate development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane. Part of Integrin alphav-beta6 complex. Is expressed in several structures, including diaphragm; gut; limb; metanephros; and vertebral axis musculature. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (Integrin subunit beta 6). [provided by Alliance of Genome Resources, Apr 2022]

Itgb6 Products (2)

mRNA Protein Name
NM_001159564.1 NP_001153036.1 integrin beta-6 precursor
NM_021359.3 NP_067334.1 integrin beta-6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
8601592 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Langerhans cell differentiation IGI
IGI: Inferred from genetic interaction
19118215 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
30467097 MGI
acts upstream of or within bronchiole development IDA
IDA: Inferred from direct assay
12634787 MGI
acts upstream of or within bronchiole development IMP
IMP: Inferred from mutant phenotype
12634787 MGI
involved in cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
24681597 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
17641300 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
23264742 MGI
acts upstream of or within cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
17916808 MGI
acts upstream of or within cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
30467097 MGI
acts upstream of or within enamel mineralization IMP
IMP: Inferred from mutant phenotype
23264742 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
12634787 MGI
acts upstream of or within negative effect gene expression IMP
IMP: Inferred from mutant phenotype
23264742 MGI
acts upstream of or within hard palate development IGI
IGI: Inferred from genetic interaction
19118215 MGI
acts upstream of or within immune response IGI
IGI: Inferred from genetic interaction
19118215 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15963261 MGI
acts upstream of or within lung alveolus development IDA
IDA: Inferred from direct assay
12634787 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
12634787 MGI
acts upstream of or within phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
17641300 MGI
acts upstream of or within response to virus IGI
IGI: Inferred from genetic interaction
30952606 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
24319098 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
12634787 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
17641300 MGI
involved in transforming growth factor beta production IDA
IDA: Inferred from direct assay
24681597 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
30952606 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12634787 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
30500364 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16710477 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9553049 MGI
part of integrin alphav-beta6 complex IDA
IDA: Inferred from direct assay
24681597 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-6

Recombinant Itgb6 Proteins

Cat. No. Product Name Accession Purity
HY-P77723 Integrin alpha V beta 6 Protein, Mouse (HEK293, His) P43406 (F31-V988)&Q9Z0T9 (G22-N706) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700769 ITGB6 Protein, Mouse (HEK293, His) Q9Z0T9 (G22-N706) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164957 Sigvotatug vedotin Inhibitor 99.68% Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990764 Sigvotatug Ligand 99.67% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06970 ITGB6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18525 Itgb6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25007 Itgb6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990667B STX-100 (Biotinylated) Inhibitor ≥99.0% Unkown
HY-P990764B Sigvotatug (Biotinylated) Ligand ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb6 NCBI NCBI:3694