ITGB7 Antibody (YA3914)(PBS only)
(Synonyms: Integrin beta-7, Integrin beta-P, M290 IEL antigen, Itgb7)ITGB7 Antibody (YA3914) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITGB7.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:50-1:200 | 1:200-1:400 | 1:10000 |
Product Details
ITGB7 Antibody (YA3914) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITGB7.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 87 kDa
Purified recombinant fragment of human ITGB7 (AA: 20-174) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ITGB7 is an Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin; (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120[1][2].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed in a variety of leukocyte lines
Induction:Induced by TGFB1 -
Isoforms & Post-Translational Modification
P26010 has 2 isomers: P26010-1: 86903 Da (predicted); P26010-2: 71582 Da (predicted).
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Subunit
Heterodimer of an alpha and a beta subunit (PubMed:1542691). ITGB7/beta-7 associates with either ITGA4/alpha-4 or ITGAE/alpha-E (PubMed:1542691). Integrin ITGA4/ITGB7 interacts with MADCAM1 (PubMed:10837471). Integrin ITGA4/ITGB7 interacts with VCAM1 and fibronectin (Probable). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450)
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SwissProt ID
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Synonyms
Integrin beta-7, Integrin beta-P, M290 IEL antigen, Itgb7
Documentation
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