ITGB7 Antibody (YA3914)(PBS only)

Cat. No.: HY-P84217A: Data Sheet User Guide for Antibodies
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ITGB7 Antibody (YA3914) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITGB7.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ITGB7 Antibody (YA3914) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITGB7.

Host

Mouse

Molecular Weight

Predicted band size: 87 kDa;

Observed band size: 130 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P26010

Gene ID

3695 [NCBI]

Immunogen

Purified recombinant fragment of human ITGB7 (AA: 20-174) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471); (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:Expressed in a variety of leukocyte lines

Induction:Induced by TGFB1

Isoforms & Post-Translational Modification：P26010 has 2 isomers: P26010-1: 86903 Da (predicted); P26010-2: 71582 Da (predicted).

Subunit：Heterodimer of an alpha and a beta subunit (PubMed:1542691). ITGB7/beta-7 associates with either ITGA4/alpha-4 or ITGAE/alpha-E (PubMed:1542691). Integrin ITGA4/ITGB7 interacts with MADCAM1 (PubMed:10837471). Integrin ITGA4/ITGB7 interacts with VCAM1 and fibronectin (Probable). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450)

Synonyms

Integrin beta-7, Integrin beta-P, M290 IEL antigen, Itgb7

Documentation

User Guide for Antibodies (1077 KB)