Excisanin A
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer.
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- CAS No.: 78536-37-5
- Formule: C20H30O5
- Masse moléculaire:350.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 21
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Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
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[PMID: 19072209] |
| MCF7 | IC50 |
>10 μM
Compound: 21
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Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay
Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay
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[PMID: 19072209] |
| NB-4 | IC50 |
8.2 μM
Compound: 21
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Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay
Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay
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[PMID: 19072209] |
| P388 | IC50 |
1.11 μg/mL
Compound: 5
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 15043413] |
| PC-3 | IC50 |
>10 μM
Compound: 21
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Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay
Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay
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[PMID: 19072209] |
| SH-SY5Y | IC50 |
>10 μM
Compound: 21
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Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay
Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay
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[PMID: 19072209] |
In Vitro
Excisanin A (5-80 µM; 24, 48, 72 h) shows antiproliferative activity in a time and dose dependent manner in MDA-MB-231, SKBR3 cells[1].
Excisanin A (10, 20, 40 µM; 24 h) inhibits cell migration, adhesion and invasion in MDA-MB-231, SKBR3 cells[1].
Excisanin A (10, 20, 40 µM; 24 h) decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein in a dose dependent manner in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, SKBR3 cells
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Concentration:5, 10, 20, 40, 80 µM
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Incubation Time:24, 48, 72 h
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Result:Inhibited the cell growth with IC50s of 22.4, 27.3 µM at 72 h for MDA-MB-231, SKBR3 cells, respectively.
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Cell Line:MDA-MB-231 cells
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Concentration:10, 20, 40 µM
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Incubation Time:24 h
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Result:Decreased the expression of MMP-2 and MMP-9 protein and mRNA level in a dose-dependent manner.
Chemical Information
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CAS No. 78536-37-5
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Masse moléculaire 350.45
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Formule C20H30O5
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SMILES
O[C@H]([C@@H]1C2=C)[C@@]([C@@H](C[C@]3([H])C4(C)C)O)(C2=O)[C@](C[C@@H]1O)([H])[C@@]3([C@H](CC4)O)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Excisanin A Related Classifications
HY-136699 Related Classifications
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