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  6. Excisanin A

Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer.

For research use only. We do not sell to patients.

Excisanin A Chemical Structure

Excisanin A Chemical Structure

CAS No. : 78536-37-5

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Excisanin A Related Antibodies

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Description

Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1].

In Vitro

Excisanin A (5-80 µM; 24, 48, 72 h) shows antiproliferative activity in a time and dose dependent manner in MDA-MB-231, SKBR3 cells[1].
Excisanin A (10, 20, 40 µM; 24 h) inhibits cell migration, adhesion and invasion in MDA-MB-231, SKBR3 cells[1].
Excisanin A (10, 20, 40 µM; 24 h) decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein in a dose dependent manner in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Excisanin A Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, SKBR3 cells
Concentration: 5, 10, 20, 40, 80 µM
Incubation Time: 24, 48, 72 h
Result: Inhibited the cell growth with IC50s of 22.4, 27.3 µM at 72 h for MDA-MB-231, SKBR3 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 10, 20, 40 µM
Incubation Time: 24 h
Result: Decreased the expression of MMP-2 and MMP-9 protein and mRNA level in a dose-dependent manner.
Molecular Weight

350.45

Formula

C20H30O5
CAS No.
SMILES

O[C@H]([C@@H]1C2=C)[C@@]([C@@H](C[C@]3([H])C4(C)C)O)(C2=O)[C@](C[C@@H]1O)([H])[C@@]3([C@H](CC4)O)C
Structure Classification
Initial Source
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Excisanin A78536-37-5Othersproliferationmigrationadhesion and invasionbreast cancerMMP-2MMP-9MDA-MB-231Inhibitorinhibitorinhibit

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