ent-Kaurane diterpenoids from Isodon scoparius

  • J Nat Prod. 2009 Jan;72(1):125-9. doi: 10.1021/np800484j.
Yong Zhao  1 ,  Jian-Xin Pu ,  Sheng-Xiong Huang ,  Ying-Li Wu ,  Li-Bin Yang ,  Wei-Lie Xiao ,  Quan-Bin Han ,  Guo-Qiang Chen ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 19072209 DOI: 10.1021/np800484j
Abstract

Nine new ent-kaurane Diterpenoids, isoscoparins D-L (1-9), and an artificial product, the acetonide of rabdoloxin A (10), along with 16 known analogues (11-26), were isolated from the leaves of Isodon scoparius. The new structures were determined by 1D and 2D NMR spectroscopic analysis. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.