JNJ-26076713
JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization.
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- CAS. Nr.: 669076-03-3
- Formel: C29H38N4O3
- Molecular Weight:490.64
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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αvβ3 2.3 nM (IC50) |
αvβ5 6.3 nM (IC50) |
JNJ-26076713 (5-5000 nM) inhibits FGF2-induced HUVEC migration in a dose-dependent manner[1].
JNJ-26076713 (0.1, 1, and 10 μg) inhibits angiogenesis in the chick chorioallantoic membrane (CAM) model in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
JNJ-26076713 (60 mg/kg; i.g.; twice daily for 5 days; diabetic Long-Evans rats) inhibits the increase in retinal vascular permeability and leukostasis associated with diabetes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice with oxygen-induced retinopathy (OIR) model[1]
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Dosage:30, 60, and 120 mg/kg
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Administration:Oral gavage, twice daily for 5 days
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Result:Inhibited retinal neovascularization with 33, 43, and 67% inhibition of neovascularization at 30, 60, and 120 mg/kg, respectively.
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Animal Model:Diabetic Long-Evans rats[1]
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Dosage:60 mg/kg
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Administration:Oral gavage, twice daily for 5 days
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Result:Reduced leukocyte adhesion with 48% and inhibited retinal vascular permeability in streptozotocin diabetic rats.
Chemical Information
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CAS. Nr. 669076-03-3
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Molecular Weight 490.64
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Formel C29H38N4O3
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SMILES
O=C(C[C@@H]([C@H]1CNC2=C(C1)C=CC=C2)CC3CCN(CC3)C(CCC4=CC=C5CCCN=C5N4)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
JNJ-26076713 Related Classifications
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