Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His)
Based on 1 Customer Validation
Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His, C-Flag labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His, C-Flag labeled tag.
Background
The Integrin alpha-X/beta-2 protein serves as a receptor for fibrinogen, recognizing the G-P-R sequence in its ligands. Crucial for cell-cell interactions during inflammatory responses, Integrin alpha-X/beta-2 plays a particularly significant role in monocyte adhesion and chemotaxis. Structurally, it forms a heterodimer, consisting of an alpha and a beta subunit, with the alpha-X subunit associating with the beta-2 subunit. This receptor's recognition of fibrinogen and its involvement in inflammatory processes underscore its importance in facilitating immune responses, emphasizing its role in the regulation of monocyte functions and cell migration during inflammation.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His;C-Flag
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Synonyms
ITGAX; Integrin Alpha-X; Prev. CD11C; Myeloid Membrane Antigen, Alpha Subunit; CD11c; P150 95 Integrin Alpha Chain; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Leu M5, Alpha Subunit; Integrin, Alpha X (Antigen CD11C (P150), Alpha Polype
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Predicted Molecular Mass
205 kDa
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Molecular Weight
Approximately 95 kDa & 130 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (232 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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