Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His)

Integrin alpha-X/beta-2, a receptor for fibrinogen, crucially recognizes the G-P-R sequence. It plays a pivotal role in inflammatory responses, especially in monocyte adhesion and chemotaxis. Structurally, forming a heterodimer, the alpha-X subunit associates with the beta-2 subunit. This receptor's fibrinogen recognition underscores its significance in immune responses, emphasizing its role in regulating monocyte functions and cell migration during inflammation. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha X beta 2 Protein, Human (HEK293, Flag-His), has molecular weight of ~95 & 130 kDa, respectively.

The Integrin alpha-X/beta-2 protein serves as a receptor for fibrinogen, recognizing the G-P-R sequence in its ligands. Crucial for cell-cell interactions during inflammatory responses, Integrin alpha-X/beta-2 plays a particularly significant role in monocyte adhesion and chemotaxis. Structurally, it forms a heterodimer, consisting of an alpha and a beta subunit, with the alpha-X subunit associating with the beta-2 subunit. This receptor's recognition of fibrinogen and its involvement in inflammatory processes underscore its importance in facilitating immune responses, emphasizing its role in the regulation of monocyte functions and cell migration during inflammation.

Human

HEK293

C-His;C-Flag

P20702 (P20-P1107)&P05107 (Q23-N700)

3687  [NCBI]&3689  [NCBI]

Approximately 95&130 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.