ITGB2 - integrin subunit beta 2 Gene

Also Known as LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3689

About ITGB2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,885,953-44,928,815 (from NCBI)

This gene has 26 transcripts (splice variants), 228 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 117.8), appendix (RPKM 80.8) and 14 other tissues.

Summary

This gene encodes an Integrin beta chain, which combines with multiple different alpha chains to form different Integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ITGB2 Products (3)

mRNA	Protein	Name
NM_000211.5	NP_000202.3	integrin beta-2 isoform 1 precursor
NM_001127491.3	NP_001120963.2	integrin beta-2 isoform 1 precursor
NM_001303238.2	NP_001290167.1	integrin beta-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ICAM-3 receptor activity	IMP IMP: Inferred from mutant phenotype	19029120	GOA
enables cell adhesion molecule binding	IMP IMP: Inferred from mutant phenotype	19029120	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12496435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12208882	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12885943	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	19703720	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	18083624	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	19029120	GOA
involved in endodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	12885943	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	12885943	GOA
involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in positive regulation of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in positive regulation of superoxide anion generation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	19029120	GOA
involved in regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12885943	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19029120	GOA
part of integrin alphaL-beta2 complex	IDA IDA: Inferred from direct assay	19029120	GOA
part of integrin alphaM-beta2 complex	IPI IPI: Inferred from physical interaction	18083624	GOA
part of integrin alphaX-beta2 complex	IPI IPI: Inferred from physical interaction	20033057	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	21193407	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB2 Protein Structure

Integrin_beta

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
769 a.a.

Protein Preferred Names	Protein Names
integrin beta-2	cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)

ITGB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGB2	P05107	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	ITGB2	P05107	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ITGB2	P05107	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	ITGB2	P05107	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	ITGB2	P05107	TGFBI	Homo sapiens	Q15582	Anti Tag CoIP	18083624
Intra	ITGB2	P05107	TGFBI	Homo sapiens	Q15582	Anti Bait CoIP	18083624
Intra	ITGB2	P05107	SCML1	Homo sapiens	Q9UN30-2	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	SCML1	Homo sapiens	Q9UN30-2	Validated Y2H	32296183
Intra	ITGB2	P05107	SCML1	Homo sapiens	Q9UN30-2	Y2H Array	32296183
Intra	ITGB2	P05107	TLN2	Homo sapiens	Q9Y4G6	Anti Bait CoIP	19234221
Intra	ITGB2	P05107	TLN2	Homo sapiens	Q9Y4G6	Pull Down	19234221
Intra	ITGB2	P05107	UPK1B	Homo sapiens	O75841	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	UPK1B	Homo sapiens	O75841	Y2H Array	32296183
Intra	ITGB2	P05107	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	ITGB2	P05107	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	ITGB2	P05107	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	ITGB2	P05107	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	ITGB2	P05107	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	RDX	Homo sapiens	P35241	ELISA	17321526
Intra	ITGB2	P05107	RDX	Homo sapiens	P35241	Pull Down	17321526
Intra	ITGB2	P05107	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	ITGB2	P05107	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	ITGB2	P05107	ABL1	Homo sapiens	P00519	Anti Bait CoIP	19234221
Intra	ITGB2	P05107	ABL1	Homo sapiens	P00519	Pull Down	19234221
Intra	ITGB2	P05107	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ITGB2	P05107	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	ITGB2	P05107	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	ITGB2	P05107	APOL2	Homo sapiens	Q9BQE5	Y2H Array	32296183
Intra	ITGB2	P05107	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	ITGB2	P05107	APOL2	Homo sapiens	Q9BQE5	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	FOXD4L6	Homo sapiens	Q3SYB3	Validated Y2H	32814053
Intra	ITGB2	P05107	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Array	32814053
Intra	ITGB2	P05107	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Pooling	32814053
Intra	ITGB2	P05107	MS4A7	Homo sapiens	Q9GZW8	Y2H Prey Pooling	32296183
Intra	ITGB2	P05107	MS4A7	Homo sapiens	Q9GZW8	Validated Y2H	32296183
Intra	ITGB2	P05107	MS4A7	Homo sapiens	Q9GZW8	Y2H Array	32296183
Intra	ITGB2	P05107	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	ITGB2	P05107	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	ITGB2	P05107	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25910212
Intra	ITGB2	P05107	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Bait-Prey Pool	25910212
Intra	ITGB2	P05107	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25910212
Intra	ITGB2	P05107	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	ITGB2	P05107	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	ITGB2	P05107	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73863	Integrin alpha X beta 2 Protein, Human (HEK293, His)	P20702 (F20-P1107)&P05107 (Q23-N700)	≥ 90%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P73864	Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His)	P20702 (P20-P1107)&P05107 (Q23-N700)	≥ 90%, as determined by reducing SDS-PAGE.

ITGB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80795	Phospho-CD18 (Ser745) Antibody (YA220)	WB, IP	Human, Mouse, Rat
HY-P80795A	Phospho-CD18 (Ser745) Antibody (YA220)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P83953	CD18 Antibody (YA3650)	ICC/IF, ELISA	Human, Mouse
HY-P83953A	CD18 Antibody (YA3650)(PBS only)	ICC/IF, ELISA	Human, Mouse
HY-P83954	CD18 Antibody (YA3651)	WB, FC, ELISA	Human
HY-P83954A	CD18 Antibody (YA3651)(PBS only)	WB, FC, ELISA	Human
HY-P85085	CD18 Antibody (YA4777)	ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Coronary Restenosis
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Pyoderma Gangrenosum	Phagedenic Pyoderma Phagedena Geometric
Pyoderma
Chronic Venous Insufficiency
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Leukocyte Adhesion Deficiency, Type Iii	Leukocyte Adhesion Deficiency 3 LAD3 Leukocyte Adhesion Deficiency 1 Variant Lad1v Integrin Activation Deficiency Disease Iadd Leukocyte Adhesion Deficiency Type Iii Lad1 Variant Lad-1 Variant Lad-Iii Leukocyte Adhesion Deficiency-1 Variant Leukocyte Adhesion Deficiency Type 1
Polyarteritis Nodosa	Polyarteritis Periarteritis Nodosa Pan Periarteritis Kussmaul-Maier Disease Panarteritis Nodosa Kussmaul Disease Pan - [Polyarteritis Nodosa] Polyangiitis Panangiitis Arteritis Nodosa
Coronary Stenosis	Coronary Artery Stenosis
Scleritis
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Glomerulonephritis	Bright'S Disease
Psoriasis
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Cutaneous Leishmaniasis	Diffuse Cutaneous Leishmaniasis Asian Desert Cutaneous Leishmaniasis Leishmaniasis, Cutaneous Leproid Leishmaniasis Leishmaniasis Diffuse Cutaneous Leishmaniasis Cutaneous Ethiopian Cutaneous Leishmaniasis Old World Cutaneous Leishmaniasis
Papillon-Lefevre Syndrome	Papillon-Lefevre Disease Papillon-Lefèvre Syndrome PLS Keratosis Palmoplantaris With Periodontopathia PALS Papillon Lefevre Syndrome Keratosis Palmoplantar-Periodontopathy Syndrome Papillon-Lefvre Syndrome Hyperkeratosis Palmoplantaris With Periodontosis Keratoris Palmoplantaris With Periodontopathia Keratosis Palmoplantar - Periodontopathy Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction Palmoplantar Keratoderma With Periodontosis Palsy
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Granulocytopenia	Agranulocytosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Periodontitis, Aggressive, 1	Pustulosis Palmaris Et Plantaris Ppp Periodontitis, Juvenile Localized Pustular Psoriasis Jpd Periodontitis 1, Juvenile Lpp Palmoplantar Pustulosis Prepubertal Periodontitis Periodontitis, Aggressive 1 Periodontitis, Prepubertal Periodontititis, Aggressive, 1 AP1 Juvenile Periodontitis Periodontitis Juvenile Pustulosis Of Palms And Soles Generalized Pustular Psoriasis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Diabetes Mellitus	Diabetes
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99946	Erlizumab	Inhibitor	98.49%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06965	ITGB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16847	Itgb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23288	Itgb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ITGB2	VGNC	VGNC:30327
Rattus norvegicus	ITGB2	RGD	RGD:1305581
Canis familiaris	ITGB2	VGNC	VGNC:42139
Felis catus	ITGB2	VGNC	VGNC:67850
Macaca mulatta	ITGB2	VGNC	VGNC:73786
Mus musculus	ITGB2	MGD	MGI:96611
Others	ITGB2	NCBI