TLN2 - talin 2 Gene

Also Known as ILWEQ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83660

About TLN2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:62,390,550-62,844,631 (from NCBI)

This gene has 11 transcripts (splice variants), 226 orthologues and 2 paralogues. Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues.

Summary

This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

TLN2 Products (2)

mRNA Protein Name
NM_001394547.1 NP_001381476.1 talin-2
NM_015059.3 NP_055874.2 talin-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10320934 GOA
Biological Process GO Annotation Evidence References Source
involved in presynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
15479735 GOA
involved in presynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15479735 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLN2 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (92 - 201)

FERM_M

FERM_M: FERM central domain (206 - 316)

IRS

IRS: PTB domain (IRS-1 type) (327 - 400)

Talin_middle

Talin_middle: Talin, middle domain (494 - 655)

VBS

VBS: Vinculin Binding Site (1850 - 1974)

I_LWEQ

I_LWEQ: I/LWEQ domain (2385 - 2531)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2542 a.a.
Protein Preferred Names Protein Names

talin-2

TLN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLN2 Q9Y4G6 ITGB2 Homo sapiens P05107
Far-WB
19234221
Intra
TLN2 Q9Y4G6 ITGB2 Homo sapiens P05107
Pull Down
19234221
Intra
TLN2 Q9Y4G6 ITGB2 Homo sapiens P05107
Anti Bait CoIP
19234221
Intra
TLN2 Q9Y4G6 ABL1 Homo sapiens P00519
Pull Down
19234221
Cross: Cross-species interaction Intra: Intraspecies interaction

TLN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83188 Talin 2 Antibody (YA2933) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Otospondylomegaepiphyseal Dysplasia, Autosomal Recessive

  • Osmed

  • Otospondylomegaepiphyseal Dysplasia

  • Chondrodystrophy With Sensorineural Deafness

  • Nance-Insley Syndrome

  • Nance-Sweeney Chondrodysplasia

  • OSMEDB

  • Insley-Astley Syndrome

  • Osmed Syndrome

  • Mega-Epiphyseal Dwarfism

  • Weissenbacher-Zweymuller Syndrome, Formerly

  • Wzs, Formerly

  • Nance Sweeney Chondrodysplasia

  • Oto-Spondylo-Mega-Epiphyseal Dysplasia

  • Oto-Spondylo-Megaepiphyseal Dysplasia

  • Megaepiphyseal Dwarfism
Aromatase Excess Syndrome

  • AEXS

  • Increased Aromatase Activity

  • Familial Hyperestrogenism

  • Hereditary Prepubertal Gynecomastia

  • Aromatase Activity, Increased

  • Familial Gynecomastia Due To Increased Aromatase Activity

  • Hereditary Gynecomastia

  • Gynecomastia, Familial

  • Familial Gynecomastia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14575 TLN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TLN2 VGNC VGNC:35898
Felis catus TLN2 VGNC VGNC:66216
Macaca mulatta TLN2 VGNC VGNC:78385
Canis familiaris TLN2 VGNC VGNC:47402
Rattus norvegicus TLN2 RGD RGD:1565416
Mus musculus TLN2 MGD MGI:1917799
Others TLN2 NCBI