HSDVHK-NH2
Based on 1 Customer Validation
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM).
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 848644-86-0
- Formula: C30H48N12O9
- Molecular Weight:720.78
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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αvβ3 2.74 nM (IC50) |
HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC cells.
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Concentration:0.1, 1, 10, and 100 μg/mL.
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Incubation Time:72 h.
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Result:Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.
Chemical Information
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CAS No. 848644-86-0
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Appearance Solid
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Molecular Weight 720.78
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Formula C30H48N12O9
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Color White to off-white
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Sequence Shortening
HSDVHK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 250 mg/mL (346.85 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (138.74 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94. [Content Brief]
[2]. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80. [Content Brief]
[3]. Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10(8):M110.005264. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3874 mL | 6.9369 mL | 13.8739 mL | 34.6846 mL |
| 5 mM | 0.2775 mL | 1.3874 mL | 2.7748 mL | 6.9369 mL | |
| 10 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
| 15 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3123 mL | |
| 20 mM | 0.0694 mL | 0.3468 mL | 0.6937 mL | 1.7342 mL | |
| 25 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3874 mL | |
| 30 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1562 mL | |
| 40 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8671 mL | |
| 50 mM | 0.0277 mL | 0.1387 mL | 0.2775 mL | 0.6937 mL | |
| 60 mM | 0.0231 mL | 0.1156 mL | 0.2312 mL | 0.5781 mL | |
| 80 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4336 mL | |
| 100 mM | 0.0139 mL | 0.0694 mL | 0.1387 mL | 0.3468 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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