1. Cytoskeleton
  2. Integrin
  3. HSDVHK-NH2

HSDVHK-NH2 

Cat. No.: HY-P1187 Purity: 99.63%
Handling Instructions

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

HSDVHK-NH2 Chemical Structure

HSDVHK-NH2 Chemical Structure

CAS No. : 848644-86-0

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5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 310 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of HSDVHK-NH2:

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Description

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2].

IC50 & Target[1]

αvβ3

2.74 nM (IC50)

In Vitro

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HUVEC cells.
Concentration: 0.1, 1, 10, and 100 μg/mL.
Incubation Time: 72 h.
Result: Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.
Molecular Weight

720.78

Formula

C₃₀H₄₈N₁₂O₉

CAS No.

848644-86-0

Sequence Shortening

HSDVHK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (346.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3874 mL 6.9369 mL 13.8739 mL
5 mM 0.2775 mL 1.3874 mL 2.7748 mL
10 mM 0.1387 mL 0.6937 mL 1.3874 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

HSDVHK-NH2IntegrinInhibitorinhibitorinhibit

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Product Name:
HSDVHK-NH2
Cat. No.:
HY-P1187
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