2. Cytoskeleton
  3. Integrin
  4. TC-I 15

TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition.

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TC-I 15 Chemical Structure

TC-I 15 Chemical Structure

CAS No. : 916734-43-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 206 In-stock
Solution
10 mM * 1 mL in DMSO USD 206 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 300 In-stock
50 mg USD 1100 In-stock
100 mg USD 1800 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

TC-I 15 Related Antibodies

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View All Integrin Isoform Specific Products:

View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].

IC50 & Target

α2β1

0.4 (α2β1 μM (IC50)

α2β1

26.8 (α2β1 μM (IC50)

α1β1

23.6 (α1β1 μM (IC50)

α1β1

24.4 (α1β1 μM (IC50)

α11β1

177 (α11β1 μM (IC50)

α11β1

3177 (α11β μM (IC50)

Molecular Weight

520.62

Formula

C23H28N4O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[S](N(CSC(C)1C)[C@@H]1C(N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O)(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (480.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9208 mL 9.6039 mL 19.2079 mL
5 mM 0.3842 mL 1.9208 mL 3.8416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9208 mL 9.6039 mL 19.2079 mL 48.0197 mL
5 mM 0.3842 mL 1.9208 mL 3.8416 mL 9.6039 mL
10 mM 0.1921 mL 0.9604 mL 1.9208 mL 4.8020 mL
15 mM 0.1281 mL 0.6403 mL 1.2805 mL 3.2013 mL
20 mM 0.0960 mL 0.4802 mL 0.9604 mL 2.4010 mL
25 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.9208 mL
30 mM 0.0640 mL 0.3201 mL 0.6403 mL 1.6007 mL
40 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2005 mL
50 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
60 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8003 mL
80 mM 0.0240 mL 0.1200 mL 0.2401 mL 0.6002 mL
100 mM 0.0192 mL 0.0960 mL 0.1921 mL 0.4802 mL
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TC-I 15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-I 15916734-43-5Integrincollagen-binding integrinGFOGERGLOGENplatelet adhesionthrombus depositioncell adhesionInhibitorinhibitorinhibit

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