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Cat. No.: HY-107588R

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TC-I 15 (Standard)

TC-I 15 (Standard) is the analytical standard of TC-I 15 (HY-107588). This product is intended for research and analytical applications. TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .

For research use only. We do not sell to patients.

CAS No.: 916734-43-5
Formula: C₂₃H₂₈N₄O₆S₂
Molecular Weight:520.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TC-I 15 (Standard) Chemical Structure

CAS No.: 916734-43-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.4 μM (α2β1 to GLOGEN), 26.8 μM (α2β1 to GFOGER), 23.6 μM (α1β1 to GFOGER), 24.4 μM (α1β1 to GLOGEN), 177 μM (α11β1 to GLOGEN), 3177 μM (α11β1 to GFOGER)^[1]

All Integrin Isoforms :

Chemical Information

CAS No. 916734-43-5
Molecular Weight 520.62
Formula C₂₃H₂₈N₄O₆S₂
SMILES

O=[S](N(CSC(C)1C)[C@@H]1C(N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O)(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Emma J. Hunter, Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol Appl Pharmacol. 2021 Oct 1;428:115669. [Content Brief]

[2]. Jing Kong, et al. Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts. Mol Cancer. 2019 Dec 3;18(1):175. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TC-I 15 (Standard)

All Integrin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TC-I 15 (Standard) Related Classifications

HY-107588R Related Classifications