T3 Peptide  (Synonyms: Tumstatin (69-88), human)

T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts^[1].

2407.79

C₁₀₉H₁₅₉N₂₇O₂₉S₃

Leu-Gln-Arg-Phe-Thr-Thr-Met-Pro-Phe-Leu-Phe-Cys-Asn-Val-Asn-Asp-Val-Cys-Asn-Phe (Disulfide bridge: Cys12-Cys18)

LQRFTTMPFLFCNVNDVCNF (Disulfide bridge: Cys12-Cys18)

O=C([C@@H](N)CC(C)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2C(C)C)=O)CC(O)=O)=O)CC(N)=O)=O)C(C)C)=O)CC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC(N)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)CC5=CC=CC=C5)=O)CCC1)=O)CCSC)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CC6=CC=CC=C6)=O)CCCNC(N)=N)=O)CCC(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yasuda J, et al., T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2017 Nov;390(11):1135-1144.  [Content Brief]