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Cat. No.: HY-149344

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Anticancer agent 133

Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1.

For research use only. We do not sell to patients.

CAS No.: 2758905-51-8
Formula: C₂₄H₁₉Cl₃N₅ORh
Molecular Weight:602.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Anticancer agent 133 Chemical Structure

CAS No.: 2758905-51-8

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

All EGFR Isoforms :

Chemical Information

CAS No. 2758905-51-8
Molecular Weight 602.71
Formula C₂₄H₁₉Cl₃N₅ORh
SMILES

Cl[Rh]12(Cl)([N]#CC)[N]3=C(C(N2C4=CC=CC=C4)=O)C(Cl)=CC=C3N5C(C6=CC=CC=C6)=CC(C)=[N]51
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gu YQ, et al. Rhodium(III)-Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. J Med Chem. 2023 Jul 27;66(14):9592-9606. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anticancer agent 133

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anticancer agent 133 Related Classifications

HY-149344 Related Classifications