2. Cytoskeleton Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. Integrin FAK Akt ERK
  4. FZ1 peptide

FZ1 peptide is an integrin αvβ3 agonist. FZ1 peptide binds to integrin αvβ3, effectively activates FAK, FAK-dependent AKT and ERK1/2 signaling pathways. FZ1 peptide enhances VEGFC-induced endothelial angiogenesis, accelerates diabetic skin wound healing.

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FZ1 peptide

FZ1 peptide Chemical Structure

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Based on 1 publication(s) in Google Scholar

FZ1 peptide Related Antibodies

Top Publications Citing Use of Products

View All Integrin Isoform Specific Products:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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View All Isoforms
Akt Akt1 Akt2 Akt3

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

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Description

FZ1 peptide is an integrin αvβ3 agonist. FZ1 peptide binds to integrin αvβ3, effectively activates FAK, FAK-dependent AKT and ERK1/2 signaling pathways. FZ1 peptide enhances VEGFC-induced endothelial angiogenesis, accelerates diabetic skin wound healing[1].

IC50 & Target[1]

αvβ3

 

ERK1

 

ERK2

 

Molecular Weight

779.88

Formula

C29H49N9O12S2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Lys-Leu-Ser-Asn-Asp-Cys (Disulfide bridge: Cys1-Cys7)
Sequence Shortening

CKLSNDC (Disulfide bridge: Cys1-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (128.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2822 mL 6.4112 mL 12.8225 mL
5 mM 0.2564 mL 1.2822 mL 2.5645 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2822 mL 6.4112 mL 12.8225 mL 32.0562 mL
5 mM 0.2564 mL 1.2822 mL 2.5645 mL 6.4112 mL
10 mM 0.1282 mL 0.6411 mL 1.2822 mL 3.2056 mL
15 mM 0.0855 mL 0.4274 mL 0.8548 mL 2.1371 mL
20 mM 0.0641 mL 0.3206 mL 0.6411 mL 1.6028 mL
25 mM 0.0513 mL 0.2564 mL 0.5129 mL 1.2822 mL
30 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0685 mL
40 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8014 mL
50 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6411 mL
60 mM 0.0214 mL 0.1069 mL 0.2137 mL 0.5343 mL
80 mM 0.0160 mL 0.0801 mL 0.1603 mL 0.4007 mL
100 mM 0.0128 mL 0.0641 mL 0.1282 mL 0.3206 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FZ1 peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FZ1 peptideIntegrinFAKAktERKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePKBProtein kinase BExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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