1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Integrin
  5. Integrin alpha 2 beta 1
  6. Integrin alpha 2 beta 1 Protein, Human (HEK293, His)

Integrin alpha 2 beta 1 Protein, Human (HEK293, His)

Cat. No.: HY-P700752
COA Handling Instructions

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

For research use only. We do not sell to patients.

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50 μg $390 In-stock
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  • Biological Activity

  • Technical Parameters

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Description

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

Background

Integrin alpha-2/beta-1, also known as ITGA2 Protein, functions as a receptor for various extracellular matrix molecules such as laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin. Specifically, it recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. This integrin is responsible for mediating the adhesion of platelets and other cells to collagens, as well as modulating the expression of collagen and collagenase genes, generating mechanical forces, and organizing newly synthesized extracellular matrix. Additionally, in the context of microbial infection, the ITGA2:ITGB1 complex acts as a receptor for Human rotavirus A.

Species

Human

Source

HEK293

Tag

C-His

Accession

P17301-1 (Y30-T1132)&P05556 (Q21-D728)

Gene ID

3673&3688

Synonyms
α2β1; Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b; Integrin alpha A1 β 1; alpha A1 β 1; β 1
Molecular Weight

110-140 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Integrin alpha 2 beta 1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Integrin alpha 2 beta 1 Protein, Human (HEK293, His)
Cat. No.:
HY-P700752
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