Integrin alpha 2 beta 1 Protein, Human (HEK293, His)

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

Integrin alpha-2/beta-1, also known as ITGA2 Protein, functions as a receptor for various extracellular matrix molecules such as laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin. Specifically, it recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. This integrin is responsible for mediating the adhesion of platelets and other cells to collagens, as well as modulating the expression of collagen and collagenase genes, generating mechanical forces, and organizing newly synthesized extracellular matrix. Additionally, in the context of microbial infection, the ITGA2:ITGB1 complex acts as a receptor for Human rotavirus A.

Human

HEK293

C-8*His

P17301-1 (Y30-T1132)&P05556 (Q21-D728)

3673&3688

Approximately 100-130 kDa & 140-170 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.