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Integrin alpha 2 beta 1 Protein, Human (HEK293, His)

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Based on 1 publication(s) in Google Scholar

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

Background

Integrin alpha-2/beta-1, also known as ITGA2 Protein, functions as a receptor for various extracellular matrix molecules such as laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin. Specifically, it recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. This integrin is responsible for mediating the adhesion of platelets and other cells to collagens, as well as modulating the expression of collagen and collagenase genes, generating mechanical forces, and organizing newly synthesized extracellular matrix. Additionally, in the context of microbial infection, the ITGA2:ITGB1 complex acts as a receptor for Human rotavirus A.

Verified Bioactivity

Immobilized Human ITGA2&ITGB1, His Tag at 1 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-ITGA2 Antibody, hFc Tag with the EC50 of 10-20 ng/mL determined by ELISA.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-8*His
  • Accession

    P17301-1 (Y30-T1132)&P05556 (Q21-D728)

  • Gene ID
    3673&3688
  • Synonyms

    ITGA2; Alpha 2 Integrin; Prev. CD49B; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; GPIa; Very Late Activation Receptor Alpha-2 Subunit; CD49 Antigen-Like Family Member B; Human Platelet Alloantigen System 5; Platelet Membrane Glycoprotein Ia;

  • Predicted Molecular Mass

    126.6 kDa (ITGA2) & 83.2 kDa (ITGB1)

  • Molecular Weight

    Approximately 100-130 kDa & 140-170 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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