Integrin alpha 2 beta 1
Integrin alpha 2 beta 1 (VLA-2, platelet GP Ia/IIa) is the major platelet collagen receptor and a broadly distributed collagen and laminin adhesion molecule. The alpha-2 I-domain coordinates a magnesium ion to bind the GFOGER motif of triple-helical collagen, and the heterodimer also engages laminin-111. It is expressed on platelets, endothelial cells, fibroblasts and epithelial cells, mediating adhesion to subendothelial matrix after vascular injury and modulating angiogenesis and wound contraction. In T cells it marks a subset of tissue-infiltrating effectors, and genetic variants affecting alpha-2 density have been linked to thrombotic risk. As a recombinant protein, alpha 2 beta 1 is a standard reagent for collagen-binding assays and inhibitor screening.
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Integrin alpha 2 beta 1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
