Integrin beta-1/CD29 Protein, Mouse (His)
Integrin beta-1/CD29 is one of the most common subunits in the integrin family. Integrin beta-1/CD29 functions as a component of a heterodimeric complex in cells, which forms an adhesion receptor with the α-integrin subunit, mediating cell signaling. Integrin beta-1/CD29 mediates cell-to-cell and cell-to-extracellular matrix interactions, participating in embryogenesis and development, differentiation and migration, inflammatory responses, hematopoietic stem cell differentiation, supramolecular assembly of extracellular matrix proteins, and tumor progression. Integrin beta-1/CD29 Protein, Mouse (His), is a recombinant Integrin beta-1/CD29 protein with a N-10*His tag.
- Species: Mouse
- Source: E. coli
-
Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Integrin beta-1/CD29 is one of the most common subunits in the integrin family. Integrin beta-1/CD29 functions as a component of a heterodimeric complex in cells, which forms an adhesion receptor with the α-integrin subunit, mediating cell signaling. Integrin beta-1/CD29 mediates cell-to-cell and cell-to-extracellular matrix interactions, participating in embryogenesis and development, differentiation and migration, inflammatory responses, hematopoietic stem cell differentiation, supramolecular assembly of extracellular matrix proteins, and tumor progression. Integrin beta-1/CD29 Protein, Mouse (His), is a recombinant Integrin beta-1/CD29 protein with a N-10*His tag[1][2][3][4].
Integrin beta-1/CD29 is a multifunctional heterodimeric glycoprotein widely involved in various physiological and pathological processes. Integrin beta-1/CD29 is highly expressed in dermal fibroblasts and articular chondrocytes, located in adhesion focal structures, and mediates cell adhesion to the extracellular matrix, including collagen, fibronectin, and laminin. Integrin beta-1/CD29 also connects actin stress fibers in myofibroblasts to the extracellular matrix, providing structural support for cellular mechanotransmission. Integrin beta-1/CD29 can activate latent TGF-β through mechanotransmission, making it a core regulatory molecule for skin wound healing. Simultaneously, Integrin beta-1/CD29 positively regulates the synthesis of type I collagen and α-smooth muscle actin. Animal experiments have shown that knockout mice are resistant to bleomycin-induced skin fibrosis and exhibit a progressive thinning of the dermis. Integrin beta-1/CD29 regulates the expression of extracellular matrix-related genes via the FAK/rac1/NOX/ROS pathway; its deletion significantly inhibits FAK phosphorylation, rac1 activity, and ROS generation. Integrin beta-1/CD29 can maintain the normal arrangement of the chondrocyte cytoskeleton, mediate cell signal transduction and intercellular communication, and play a role in stabilizing chondrocyte phenotype, inhibiting cell apoptosis, and regulating the expression of chondrocyte-specific genes [1][2][3][4].
Technical Parameters
-
Species Mouse
-
Source E. coli
-
Tag N-10*His
-
Accession
P09055 (Q21-K798)
-
Gene ID16412
-
Protein Length
Full Length of Mature Protein
-
Synonyms
ITGB1; Very Late Activation Protein, Beta Polypeptide; Prev. MSK12; Integrin VLA-4 Beta Subunit; Prev. FNRB; VLA-4 Subunit Beta; Prev. MDF2; Integrin Beta 1; GPIIA; Integrin Beta; Integrin Beta-1; CD29 Antigen; CD29; VLA-BETA; Integrin, Beta 1 (Fibronecti
-
AA Sequence
QTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESETIKIKPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
-
Predicted Molecular Mass
87.6 kDa
-
Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[2]. Sun L, et al. The characteristics and the multiple functions of integrin β1 in human cancers. J Transl Med. 2023 Nov 6;21(1):787. [Content Brief]
[3]. Leask A. Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts. Adv Wound Care (New Rochelle). 2013 May;2(4):160-166. [Content Brief]
[4]. Shakibaei M, et al. Diverse roles of integrin receptors in articular cartilage. Adv Anat Embryol Cell Biol. 2008;197:1-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
