2. Cytoskeleton
  3. Integrin
  4. Fibrin

Fibrin is an insoluble protein found in blood that is produced in response to bleeding. As the main component of blood clots, fibrin functions in blood coagulation. Fibrin binds to the integrins ICAM-1, VE-cadherin, αIIbβ3, αMβ2, αvβ3 and α5β1. Fibrin is used in research related to chronic wounds.

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Fibrin

Fibrin Chemical Structure

CAS No. : 9001-31-4

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Based on 1 publication(s) in Google Scholar

Fibrin Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Fibrin is an insoluble protein found in blood that is produced in response to bleeding. As the main component of blood clots, fibrin functions in blood coagulation. Fibrin binds to the integrins ICAM-1, VE-cadherin, αIIbβ3, αMβ2, αvβ3 and α5β1. Fibrin is used in research related to chronic wounds[1].

In Vitro

Fibrin enhances endothelial cell adhesion, spreading, migration, and signaling via integrin-dependent mechanisms, and stabilizes αvβ3-integrin expression on human microvascular endothelial cells to support migration[1].
Fibrin directly supports endothelial cell tube formation in in vitro as part of angiogenic responses[1].
Fibrin stimulates fibroblast proliferation, integrin expression, and migration during in vitro wound-healing processes[1].
Fibrin mediates endothelial cell adhesion and angiogenesis via multiple receptor interactions, including integrins αvβ3/α5β1, ICAM-1, and VE-cadherin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fibrin Related Antibodies
Clinical Trial
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

[Fibrin]
Structure Classification
Initial Source

bovine blood
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1 M NaOH : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

SDS (251 KB)

COA (242 KB)

Handling Instructions (2659 KB)
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Fibrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fibrin9001-31-4Integrinαvβ3human microvascular endothelial cellsαIIbβ3α5β1 integrinsVE-cadherinICAM-1myofibroblastfibroblastmonocyteαMβ2Inhibitorinhibitorinhibit

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