Synstatin (92-119)  (Synonyms: SSTN92-119)

Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupts the formation of the syndecan-1 : integrin : IGF1R ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma^[1][2].

Synstatin (92-119) directly inhibits the assembly of the Sdc1:αvβ3 integrin:IGF1R ternary complex in a cell-free system^[1].
Synstatin (92-119) directly binds to αvβ3 integrin, αvβ5 integrin, and IGF1R on activated vascular endothelial cells^[1].
Synstatin (92-119) potently inhibits αvβ3-dependent adhesion and migration of tumor cells in vitro, with an IC₅₀ of 100-300 nM^[1].
Synstatin (92-119) (100 nM, 300 nM) potently inhibits VEGF- and αvβ3-dependent angiogenesis in vitro, with an IC₅₀ of 100-300 nM^[1].
Synstatin (92-119) inhibits VE-cadherin-induced activation of the Sdc1-coupled IGF1R:αvβ3 integrin complex in vascular endothelial cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SSTN92-119 (100 μL of 100 μM in 0.2 mL PBS; subcutaneous; twice per day; 4 weeks) significantly reduces HCC progression in thioacetamide-induced rats by reversing liver dysfunction, oxidative stress, and angiogenic/proliferative markers, including a reduction in serum AST activity to 151.7 U/L and reversal of HCC grade from 3 to 1^[2].
SSTN92-119 (100 μL of 100 μM in 0.2 mL PBS; subcutaneous; twice per day; 16 weeks) administration for 16 weeks does not induce liver damage or changes in measured biochemical, histopathological, or molecular parameters in healthy rats, with serum AST activity remaining at 116.60 U/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3032.27

C₁₃₃H₂₀₇N₃₅O₄₆

1259384-47-8

Solid

White to off-white

Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu

LPAGEKPEEGEPVLHVEAEPGFTARDKE

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Rapraeger AC, et al. Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 2013;280(10):2207-2215.  [Content Brief]

  [2]. Metwaly HA, et al. Inhibition of the signaling pathway of syndecan-1 by synstatin: A promising anti-integrin inhibitor of angiogenesis and proliferation in HCC in rats. Arch Biochem Biophys. 2018;652:50-58.  [Content Brief]