2. Cytoskeleton
  3. Integrin
  4. Abituzumab

Abituzumab  (Synonyms: EMD 525797; DI17E6)

Cat. No.: HY-P99183 Purity: 99.38%
COA

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Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer.

For research use only. We do not sell to patients.

Abituzumab Chemical Structure

Abituzumab Chemical Structure

CAS No. : 1105038-73-0

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Abituzumab Related Antibodies

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Description

Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer[1].

IC50 & Target

Integrin αV[1].
In Vitro

Abituzumab (DI17E6) (0.01, 0.1, 1, 10, 30,100 µg/mL; 24 h) inhibits adhesion of PCa cells to multiple extracellular matrix proteins but not collagen I[1]
Abituzumab (100 µg/mL; 12, 18 h) inhibits inhibits motility and invasion of PCa cells[1].
Abituzumab (0.01, 0.1, 1, 10, 30,100 µg/mL; 24 h) inhibits the ability of PCa cells to adhere to osteoblast and bone stromal cell lines[1].
Abituzumab (100 µg/mL; 24 h) blocks integrin-mediated cell signaling in PCa cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abituzumab Related Antibodies

Cell Viability Assay[1]

Cell Line: PCa cells
Concentration: 0.01, 0.1, 1, 10, 30,100 µg/mL
Incubation Time: 24 h
Result: Promoted detachment of PCa cells from vitronectin (up to approximately 20% cells detached at 100 μg/mL), osteopontin (up to approximately 10% cells detached at 100 μg/mL) and fibronectin (up to approximately 10% cells detached at 100 μg/mL) but not from collagen I.

Cell Invasion Assay[1]

Cell Line: PCa cells
Concentration: 100 µg/mL
Incubation Time: 12, 18 h
Result: Inhibited invasive ability by approximately 25 to 30% compared to vehicle, and inhibited motility by approximately 30 to 40%.

Cell Viability Assay[1]

Cell Line: PCa, hFOB, Saos2, HS-5, HDMEC cells
Concentration: 0.01, 0.1, 1, 10, 30,100 µg/mL
Incubation Time: 24 h
Result: Inhibited PCa cells adhesion to human osteoblast cell lines hFOB and Saos2 and a bone marrow stromal cell line, HS-5.
Promoted detachment of PCa cells from to a known expressor of αv integrins, HDMEC cells.

Western Blot Analysis[1]

Cell Line: PC3, DU145, C4-2B, LNCaP, ARCaP and VCaP cells
Concentration: 100 µg/mL
Incubation Time: 24 h
Result: Inhibited FAK phosphorylation starting at 12 h and 6 h in C4-2B and LNCaP, respectively; AKT phosphorylation starting at 3 h and 2 h in C4-2B and LNCaP, respectively; and ERK phosphorylation at starting at 1 h and 1.5 h in C4-2B and LNCaP, respectively.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Abituzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.38%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Abituzumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abituzumab1105038-73-0EMD 525797 DI17E6EMD525797EMD-525797IntegrinPC3DU145C4-2BLNCaPARCaP,VCaPprostate cancerInhibitorinhibitorinhibit

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