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  3. R-BC154 acetate

R-BC154 acetate 

Cat. No.: HY-136214
Handling Instructions

R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.

For research use only. We do not sell to patients.

R-BC154 acetate Chemical Structure

R-BC154 acetate Chemical Structure

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Description

R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity[1].

IC50 & Target[1]

α9β1

 

In Vitro

R-BC154 acetate has 3 times greater affinities for α9β1 (Ki=12.7 nM) relative to α4β1 (Ki=38.0 nM) under Ca2+/Mg2+ conditions in human glioblastoma LN18 cell lines[1].

In Vivo

R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice[1].

Animal Model: C57Bl/6 mice (6-8 weeks old)[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Was capable of binding haemopoietic progenitor cells and HSC within mice bone marrow in vivo.
Molecular Weight

1184.36

Formula

C₅₆H₆₅N₉O₁₄S₃

SMILES

CCN(C1=CC2=[O+]C3=C(C=CC(N(CC)CC)=C3)C(C4=CC=C(S(=O)(NCC5=CN([[email protected]]6CN(S(=O)(C7=CC=CC=C7)=O)[[email protected]](C(N[[email protected]](C(O)=O)CC8=CC=C(ON9CCCC9)C=C8)=O)C6)N=N5)=O)C=C4S(=O)(O)=O)=C2C=C1)CC.CC([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

R-BC154IntegrinfluorescentintegrinprobebonemarrowhaemopoieticstemcellsphenotypesInhibitorinhibitorinhibit

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R-BC154 acetate
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HY-136214
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