2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. AT1412

AT1412 is a CD9-binding antibody. AT1412 binds to the tetraspanin protein CD9 and modulates CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration. AT1412 binds to B-ALL cell lines but not to T-ALL. AT1412 induces antibody-dependent cellular cytotoxicity in B-ALL cell lines. AT1412 binds to melanoma cells, B-ALL, gastric cancer, colorectal cancer, and pancreatic cancer cells [1] .

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AT1412

AT1412 Chemical Structure

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AT1412 Related Antibodies

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Description

AT1412 is a CD9-binding antibody. AT1412 binds to the tetraspanin protein CD9 and modulates CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration. AT1412 binds to B-ALL cell lines but not to T-ALL. AT1412 induces antibody-dependent cellular cytotoxicity in B-ALL cell lines. AT1412 binds to melanoma cells, B-ALL, gastric cancer, colorectal cancer, and pancreatic cancer cells [1] [2].

Species Reactivity

Human
IC50 & Target

CD9

 

In Vitro

AT1412 binds thetetraspanin CD9, can regulate CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration [2].
AT1412 induces antibody-dependent cytotoxicity in B-ALL cell lines SUP-B15, MHH-CALL-2 and CCRF-SB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AT1412 Related Antibodies
In Vivo

AT1412 (up to 10 mg/kg) is well tolerated in non-human primates[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

928  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AT1412 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT1412AT14-012AT 1412AT-1412Transmembrane GlycoproteinB-ALL blastsantibody dependent cellular cytotoxicityA375-CD9KOCD8 T-cellICAM-1A375 melanomaA375wtADCPB-ALLeffector cellsmelanoma cellsLFA-1CD9human immune system mouse modelsgranulocyticVLA-4lymphocytic populationsmetastatic melanomaT cellstetraspanin CD9endothelial cellscolon cancer cellsADCCmonocyticHIS mouse modelsnivolumabSK-MEL5 melanoma cellsPD-1 resistant SK-MEL5 melanoma modelpancreatic cancer cellsgastric cancer cellsHUVEC cellsantibody-dependent cellular phagocytosisNSG micecd9 positive precursor b-acute lymphoblastic leukemiamacrophageintegrin signalingVCAM-1Inhibitorinhibitorinhibit

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AT1412
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HY-P991896
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