2. Cytoskeleton
  3. Integrin
  4. α5β1 integrin-IN-1

α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research.

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α5β1 integrin-IN-1

α5β1 integrin-IN-1 Chemical Structure

CAS No. : 2649899-08-9

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α5β1 integrin-IN-1 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research[1].

IC50 & Target[1]

α5β1

9.4 (pIC50)

αvβ3

5.5 (pIC50)

Molecular Weight

629.47

Formula

C29H27Cl2FN6O5
CAS No.
SMILES

ClC1=C(C(N[C@@H](CNC(CNC(C2=CC(NC3=NCC(F)CN3)=CC=C2)=O)=O)C(O)=O)=O)C(Cl)=CC(C4=CC=CC=C4)=C1
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Purity & Documentation
References
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α5β1 integrin-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α5β1 integrin-IN-12649899-08-9Integrinintegrinairway smooth muscleinhalation pharmacokineticsrodentasthmaInhibitorinhibitorinhibit

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