α5β1 integrin-IN-1
α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research.
For research use only. We do not sell to patients.
- CAS No.: 2649899-08-9
- Formula: C29H27Cl2FN6O5
- Molecular Weight:629.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
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α5β1 9.4 (pIC50) |
αvβ3 5.5 (pIC50) |
Chemical Information
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CAS No. 2649899-08-9
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Molecular Weight 629.47
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Formula C29H27Cl2FN6O5
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SMILES
ClC1=C(C(N[C@@H](CNC(CNC(C2=CC(NC3=NCC(F)CN3)=CC=C2)=O)=O)C(O)=O)=O)C(Cl)=CC(C4=CC=CC=C4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α5β1 integrin-IN-1 Related Classifications
HY-180057 Related Classifications
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