2649899-08-9
2649899-08-9
Chemical Structure
α5β1 integrin-IN-1
- CAS No.: 2649899-08-9
- Formula:C29H27Cl2FN6O5
- Molecular Weight:629.47
InChIKey: PTROUJKHFDTUIK-QHCPKHFHSA-N
SMILES: ClC1=C(C(N[C@@H](CNC(CNC(C2=CC(NC3=NCC(F)CN3)=CC=C2)=O)=O)C(O)=O)=O)C(Cl)=CC(C4=CC=CC=C4)=C1
Biological Activity: α5β1 integrin-IN-1 is a potent and selective α5β1 integrin inhibitor with an IC50 value of approximately 0.4 nM (pIC50 = 9.4 M). α5β1 integrin-IN-1 disrupts the interaction between α5β1 integrin and fibronectin, thereby blocking smooth muscle tension transmission and α5β1 integrin-mediated cell adhesion. α5β1 integrin-IN-1 can be used in the research of asthma and allergic asthma.
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α5β1 integrin-IN-1 | α5β1 integrin-IN-1 is a potent and selective α5β1 integrin inhibitor with an IC50 value of approximately 0.4 nM (pIC50 = 9.4 M). α5β1 integrin-IN-1 disrupts the interaction between α5β1 integrin and fibronectin, thereby blocking smooth muscle tension transmission and α5β1 integrin-mediated cell adhesion. α5β1 integrin-IN-1 can be used in the research of asthma and allergic asthma. | |||||||||||||||||||||
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