2649899-08-9
Chemical Structure
α5β1 integrin-IN-1
- CAS No.: 2649899-08-9
- Formula:C29H27Cl2FN6O5
- Molecular Weight:629.47
InChIKey: PTROUJKHFDTUIK-QHCPKHFHSA-N
SMILES: ClC1=C(C(N[C@@H](CNC(CNC(C2=CC(NC3=NCC(F)CN3)=CC=C2)=O)=O)C(O)=O)=O)C(Cl)=CC(C4=CC=CC=C4)=C1
Biological Activity: α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research[1].
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α5β1 integrin-IN-1 | α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research. | |||||||||||||||||||||
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Keywords
