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Zifcasiran

(Synonyms: ADS-007; ARO HIF2)

Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation.

For research use only. We do not sell to patients.

  • CAS No.: 2437257-11-7
  • Formula: C737H972F20N211O349P43S8
  • Molecular Weight:20339.13
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure
CAS No.: 2437257-11-7
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All HIF/HIF Prolyl-Hydroxylase Isoforms

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  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-
    1/16
  • RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-