2437257-11-7
Chemical Structure
Zifcasiran
Synonym(s): ADS-007; ARO HIF2
- CAS No.: 2437257-11-7
- Formula:C737H972F20N211O349P43S8
- Molecular Weight:20339.13
IUPAC Name: ammonium ((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl-1,3-15N2)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
SMILES: [Zifcasiran]
Biological Activity: Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation[1].
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Zifcasiran | Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation. | |||||||||||||||||||||
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Keywords
