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Zifcasiran sodium

(Synonyms: ADS-007 sodium; ARO HIF2 sodium)

Zifcasiran (ADS-007) sodium is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation.

For research use only. We do not sell to patients.

  • CAS No.: 2437257-12-8
  • Formula: C737H929F20N211Na52O349P43S8
  • Molecular Weight:21491.26
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Zifcasiran sodium Chemical Structure
    Zifcasiran sodium Chemical Structure
CAS No.: 2437257-12-8
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Use of MCE Products

All HIF/HIF Prolyl-Hydroxylase Isoforms

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  • Zifcasiran sodium Chemical Structure
    Zifcasiran sodium Chemical Structure RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin
    1/16
  • RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin