2437257-12-8
Chemical Structure
Zifcasiran sodium
Synonym(s): ADS-007 sodium; ARO HIF2 sodium
- CAS No.: 2437257-12-8
- Formula:C737H929F20N211Na52O349P43S8
- Molecular Weight:21491.26
SMILES: [Zifcasiran (sodium)]
Biological Activity: Zifcasiran (ADS-007) sodium is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation[1].
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Zifcasiran sodium | Zifcasiran (ADS-007) sodium is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation. | |||||||||||||||||||||
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Keywords
