Tirofiban hydrochloride (Synonyms: L700462 hydrochloride; MK383 hydrochloride)

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Tirofiban (L700462) hydrochloride is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.

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Tirofiban hydrochloride Chemical Structure

CAS No. : 142373-60-2

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Other In-stock Forms of Tirofiban hydrochloride:

Tirofiban hydrochloride monohydrate Tirofiban

Other Forms of Tirofiban hydrochloride:

Tirofiban hydrochloride monohydrate In-stock
Tirofiban In-stock

1 Publications Citing Use of MCE Tirofiban hydrochloride

•Front Pharmacol. 2021 Oct 8:12:734603. [Abstract]

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Gp IIb/IIIa receptor^[1].

In Vitro

Tirofiban hydrochloride (0.25, 1, 3 μg/mL; 72 hours) increases proliferation of HAEC cells^[1].
Tirofiban hydrochloride (24 hours) closes the scratch of HUVECs migration within 18 hours^[1].
Tirofiban hydrochloride (0.25, 1 μg/mL; 1 hour) induces production of VEGF after 30 minutes which can stimulates proliferation of endothelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HAEC cells
Concentration:	0.25, 1, 3 μg/mL
Incubation Time:	72 hours
Result:	Increased proliferation of HAEC cells.

Cell Migration Assay ^[1]

Cell Line:	HUVEC cells
Concentration:
Incubation Time:	24 hours
Result:	Stimulated the migratory capacity of endothelial cells.

Western Blot Analysis^[1]

Cell Line:	HAEC cells
Concentration:	0.05, 0.12, 0.25, 1 μg/mL
Incubation Time:	1 hour
Result:	Induced production of VEGF which stimulated proliferation of endothelial cells.

In Vivo

Tirofiban hydrochloride (60 μg/kg; i.v.; once) shows activity of increasing contraction force, ventricular compliance, and improving heart function by increasing HR, LVESP, dp/dtmax, and reducing LVEDP^[2].
Tirofiban hydrochloride (60 μg/kg; i.v.; once) enhances eNOS activity, decreases iNOS activity and reduces area of no-reflow after reperfusion following AMI^[2].
Tirofiban hydrochloride (50 µg/per; irrigate; once) shows anticoagulant effect with patency rates of 59% at 24 hours after microvascular anastomosis in the crush model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (10 to 15-week-age; 270-330 g)^[2].
Dosage:	60 μg/kg
Administration:	Intravenous injection; once.
Result:	Increased contraction force, ventricular compliance, and improved heart function. Reduced the size of no-reflow and infarct.

Animal Model:	Sprague-Dawley rats (350-400 g; crush injury model)^[3]
Dosage:	50 µg/per (50 µg/mL, 1 mL for each)
Administration:	Irrigate 1 mL within the vessel lumen (before placement of the last suture); once.
Result:	Showed anticoagulant effect with patency rates of 59%.

Clinical Trial

Molecular Weight

477.06

Formula

C₂₂H₃₇ClN₂O₅S

CAS No.

142373-60-2

SMILES

CCCCS(N[C@H](C(O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)(=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Giordano A, et al. Tirofiban induces VEGF production and stimulates migration and proliferation of endothelial cells. Vascul Pharmacol. 2014 May-Jun;61(2-3):63-71. [Content Brief]

[2]. Liu X, et al. Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction. J Geriatr Cardiol. 2013 Mar;10(1):52-8. [Content Brief]

[3]. Yates YJ, et al. The effect of tirofiban on microvascular thrombosis: crush model. Plast Reconstr Surg. 2005 Jul;116(1):205-8. [Content Brief]

Tirofiban hydrochloride Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tirofiban142373-60-2L700462MK383L 700462L-700462MK 383MK-383IntegrinACSsAMINRHUVECHAECVEGFantithromboticInhibitorinhibitorinhibit

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